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Descriptor English: Caspase 2
Descriptor Spanish: Caspasa 2
Descriptor caspasa 2
Entry term(s) CASP2
procaspasa 2
proteasa ICH-1
Scope note: Caspasa con un prodominio largo que contiene un dominio de reclutamiento de caspasas en su región prodominio. La activación de esta enzima puede ocurrir a través de la interacción de su dominio de reclutamiento de caspasas con PROTEÍNAS ADAPTADORAS DE SEÑALIZACIÓN CARD. La caspasa 2 interviene en la APOPTOSIS mediante la escisión y activación de procaspasas efectoras. Existen diversas isoformas de esta proteína debido a las múltiples alternativas de corte y empalme de su ARN MENSAJERO.
Descriptor Portuguese: Caspase 2
Descriptor French: Caspase-2
Entry term(s): Caspase 2 Subunit p12
Caspase 2 Subunit p13
Caspase 2 Subunit p18
Caspase-2
ICH 1 Protease
ICH-1 Protease
Pro Caspase 2
Pro-Caspase-2
Procaspase 2
Procaspase-2
Tree number(s): D08.811.277.656.262.500.126.550.200
D08.811.277.656.300.200.126.550.200
D12.776.476.075.405.550.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053143
Scope note: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Caspase Inhibitors
Registry Number: EC 3.4.22.-
Public MeSH Note: 2007; CASPASE 2 was indexed under CASPASES 1994-2006
History Note: 2007(1994)
DeCS ID: 52226
Unique ID: D053143
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2015/11/23
Caspase 2 - Preferred
Concept UI M0236588
Scope note A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Preferred term Caspase 2
Entry term(s) Caspase-2
ICH 1 Protease
ICH-1 Protease
Procaspase-2 - Narrower
Concept UI M0386488
Preferred term Procaspase-2
Entry term(s) Pro Caspase 2
Pro-Caspase-2
Procaspase 2
Caspase 2 Subunit p18 - Narrower
Concept UI M0491614
Preferred term Caspase 2 Subunit p18
Caspase 2 Subunit p12 - Narrower
Concept UI M0491616
Preferred term Caspase 2 Subunit p12
Caspase 2 Subunit p13 - Narrower
Concept UI M0491615
Preferred term Caspase 2 Subunit p13



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